文部科学省 科学研究費補助金 学術変革領域研究 (A) 2023〜2027年度
FY2023-2027 MEXT KAKENHI Grant-in-Aid for Transformative Research Area (A)
Achievements
multimodal.ecm[at]gmail.com (Please replace [at] with @)
52) Collagen fiber and cellular dynamics of axolotl skin with aging
Shima C, Ohashi A, Furukawa S, Yamamoto S, Kashmoto R, and Satoh A
Dev. Growth Differ., in press
51) AP2A1 modulates cell states between senescence and rejuvenation
Chantachotikul P, Liu S, Furukawa K, and Deguchi S
Cell. Signal., 127:111616 (2025)
50) Stiff extracellular matrix activates the transcription factor ATF5 to promote proliferation of cancer cells
Ishihara S, Enomoto A, Sakai A, Iida T, Tange S, Kioka N, Nukuda A, Ichikawa Nagasato A, Yasuda M, Tokino T, Haga H
49) Cell position-based evaluation of mechanical features of cells in multicellular systems
Koyama H, Ito AM, Okumura H, Otani T, Nakamura K, and Fujimori T
J. Theor. Biol., 607 (7):112070 (2025)
48) Impacts of Structural Properties of Myosin II Filaments on Force Generation
Ding S, Chou P-E, Deguchi S, and Kim T
47) Keratinocyte-driven dermal collagen formation in the axolotl skin
Ohashi A, Sakamoto H., Kuroda J., Kondo Y.,Kamei Y., Nonaka S., Furukawa S., Yamamoto S., and Satoh A.,
Nat. Commun., 16(1):1757（2025）
46) Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis
Ogata S, Ito S, Masuda T, and Ohtsuki S
Fluids Barriers CNS, 21(1):106 (2024)
45) Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice
Hossain AS, Clarin M, Kimura K, Biggin G, Taga Y, Uto K, Yamagishi A, Motoyama E, Narenmandula, Mizuno K, Nakamura C, Asano K, Ohtsuki S, Nakamura T, Kanki S, Baldock C, Raja E, and Yanagisawa H
Matrix Biol., 135:24-38 (2025)
44) Self-organized patterning of peristaltic waves by suppressive actions in a developing gut
Kawamura K, Kato S, Utsunomiya S, Takahashi Y, and Inaba M
43) Progressive Amyloid-β Accumulation in the Brain leads to Altered Protein Expressions in the Liver and Kidneys of APP knock-in Mice
Ito S, Iwata Y, Otsuka M, Kaneko Y, Ogata S, Yagi R, Uemura T, Masuda T, Saito T, Saido T, and Ohtsuki S
J. Pharm. Sci., 3549(24)00503-3 (2025)
42) Functional analysis of regenerated digit in newt following complete amputation at proximal interphalangeal joint
Kasahara T, Teramoto M, Agata K, Kim J, Matsumoto T, and Maeda E
J. Biomech. Sci. Eng., 20 (2): 24-00276 (2025).
41) Diffusion model predicts the geometry of actin cytoskeleton from cell morphology
Li H, Liu S, Deguchi S, Matsunaga M
PLoS Comput. Biol., 20(8):e1012312 (2024)
40) The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles
Yagasaki R, Nakamura R, Shikaya Y, Tadokoro R, Hao R, Wang Z, Eiraku M, Inaba M, and Takahashi Y
39) Improving Proteomic Identification Using Narrow Isolation Windows with Zeno SWATH Data-Independent Acquisition
Gu K, Kumabe H, Yamamoto T, Tashiro N, Masuda T, Ito S, and Ohtsuki S
J. Proteome Res., 23(8):3484-349 (2024)
38) Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy
Buenaventura A, Saito T, Kanao T, Matsunaga D, Matsui TS, and Deguchi S
37) Asymmetric response emerges between creation and disintegration of force-bearing subcellular structures as revealed by percolation analysis
Ueda Y, Matsunaga D, Deguchi S
Integr. Biol. , 16:zyae012 (2024)
36) Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease
Ito S, Yagi R, Ogata S, Masuda T, Saito T, Saido T, and Ohtsuki S
Fluids Barriers CNS, 20(1):66 (2023)
35) miR-PAIR: microRNA-protein analysis of integrative relationship for the identification of significantly working miRNAs
Akai M, Maeda Y, Kawami M, Yumoto R, Takano M, Uchida Y
Biochim. Biophys. Acta - Gen. Subj., 1869(2):130746(2025).
34) Fgf8 contributes to the pathogenesis of Nager syndrome
1 Ulhaq Z.S., You M.S., Yabe T., Takada S., Chen J.K., Ogino Y., Jiang Y.J., Tse W.K.F.
Int. J. Biol. Macromol., 280:135692(2024).
33) application of cysteinyl prolyl ester for the synthesis of cyclic peptides containing an RGD sequence and their biological activity measurement
Yamada A, Takei T, Kawakami T, Taniguchi Y, Sekiguchi K, and Hojo H
Front. Chem., 12:1391678 (2024).
32) Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study
Ramsay E, Montaser AB, Niitsu K, Urtti A, Auriola S, Huttunen KM, Uchida Y, Kidron H, Terasaki T
Mol. Pharm., 21(7):3204-3217(2024).
31) Abemaciclib-induced epithelial-mesenchymal transition mediated by cyclin-dependent kinase 4/6 independent of cell cycle arrest pathway
Yoshimori T, Kawami M, Kumagai Y, Futatsugi S, Yumoto R, Uchida Y, Takano M
Int. J. Biochem. Cell Biol., 172:106601(2024).
30) ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II
Yuasa H, Morino N, Wagatsuma T, Munekane M, Ueda S, Matsunaga M, Uchida Y, Katayama T, Katoh T, Kambe T
29) Regulation of swelling behaviour while preserving bulk modulus in hydrogels via surface grafting
Nishimoto T, Akimoto A M, Enomoto T, Lin C-H, Luo S-C, and Yoshida R
Soft Matter, 21:356-360 (2025)
28) Effective mechanical potential of cell–cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis
Koyama H, Okumura H, Otani T, Ito AM, Nakamura K, Kato K, and Fujimori T
Front. Cell Dev. Biol., 12 (2024)
27) Numerical assessment of the applicability of geometry-based force inference on homogeneous and heterogeneous cells
Miyasaka S, Izumi K, Okuda S and Miki Y
PLOS ONE, 19(4):e0299016 (2024).
26) Improvement of the Green-Red Förster Resonance Energy Transfer-Based Ca2+ Indicator by Using the Green Fluorescent Protein, Gamillus, with a Trans Chromophore as the Donor
Matsuda T, Sakai S, Okazaki KI, and Nagai T
ACS Sens., 9(4):1743-1748 (2024).
25) Heparan sulfate chain-conjugated laminin-E8 fragments advance paraxial mesodermal differentiation followed by high myogenic induction from hiPSCs
Zhao M, Taniguchi Y, Shimono C, Jonuchi T, Cheng Y, Shimizu Y, Nalbandian M, Yamamoto T, Nakagawa M, Sekiguchi K, and Sakurai H
24) Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto DM, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T.
EMBO J., 42(22):e114032.(2023)
23) Apelin provides an alternative function to estrogen in regulating lymphatic vascular integrity
Sawane M, Gantumur E, Muramatsu F, Kidoya H, Takakura N, Kajiya K.
J. Dermatol. Sci., 111(3):124-127(2024)
22) Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos
Utsumi H., Yabe T, Koshida S., Yamashita A., and Takada S.
Front. Cell Dev. Biol., 12:1375655 (2024)
21) Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel
Wang Z, Numada A, Wagai F, Oda Y, Ohgushi M, Maki K, Adachi T, and Eiraku M
20) Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model
Matsui Y, Muramatsu F, Nakamura H, Noda Y, Matsumoto K, Kishima H, and Takakura N
19) The humidity responsiveness of a poly(N-isopropylacrylamide) gel using a PEG/water mixed solution as the solvent
Makita R, Akimoto A, Enomoto T, Nishimoto T, Li X, Shibayama M, Yoshida R
Polymer J., 56, 639-642 (2024)
18) Single-cell colocalization analysis using a deep generative model
Kojima Y, Mii S, Hayashi S, Hirose H, Ishikawa M, Akiyama M, Enomoto A, Shimamura T
17) Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion.
Tran THN, Takada R, Elena Krayukhina E, Maruno T, Mii Y, Uchiyama S, and Takada S
16) Dissection of N-deacetylase and N-sulfotransferase activities of NDST1 and their effects on Wnt8 distribution and signaling in Xenopus embryos
Suzuki M, Takada S, and Mii Y
Dev. Growth. Differ.,in press.
15) Surface Glycan Profiling of Extracellular Vesicles by Lectin Microarray and Glycoengineering for Control of Cellular Interactions
Shimoda A and Akiyoshi K
14) In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells
Seto Y, Ogihara R, Takizawa K, and Eiraku M
13) Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties
Konishi H, Rahmawati FN, Okamoto N, Akuta K, Inukai K, Jia W, Muramatsu F, and Takakura N
12) Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice
Shimizu S, Iba T, Naito H, Rahmawati FN, Konishi H, Jia W, Muramatsu F, and Takakura N
Angiogenesis,26:567-580 (2023).
11) Efficient selection of knocked-in pluripotent stem cells using a dual cassette cellular elimination system.
Nakade K, Tsukamoto S, Nakashima K, An Y, Sato I, Li J, Shimoda Y, Hemmi Y, Miwa Y, and Hayashi Y
Cell Rep. methods,3:100662 (2023)
10) Optogenetic control of gut movements reveals peristaltic wave-mediated induction of cloacal contractions and reactivation of impaired gut motility
Shikaya Y, Inaba M, Tadokoro R, Utsunomiya S, and Takahashi Y
Front. Physiol., Sec. Developmental Physiology, 14 (2023)
9) UNMF: a unified nonnegative matrix factorization for multi-dimensional omics data
Abe K and Shimamura T
Brief. Bioinform.,24:bbad253 (2023)
8) Topological data analysis of protein structure and inter/intra-molecular interaction changes attributable to amino acid mutations
Koseki J, Hayashi S, Kojima Y, Hirose H, and Shimamura T
Comput. Struct. Biotechnol. J.,21:2950 (2023).
7) Rapid and Highly Efficient Purification of Extracellular Vesicles Enabled by a TiO2 Hybridized Spongy-like Polymer
Kanao E, Ishida K, Mizuta R, Li Y, Imami K, Tanigawa T, Sasaki Y, Akiyoshi K, Adachi J, Otsuka K, Ishihama Y, and Kubo T*
Anal. Chem.,95, 38, 14502 (2023)
6) Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells
Cheng YS, Taniguchi Y, Yunoki Y, Masai S, Nogi M, Doi H, Sekiguchi K, and Nakagawa M
5) Visualization of basement membranes by a nidogen-based fluorescent reporter in mice
Futaki S, Horomoto A, Shimono C, Norioka N, Taniguchi Y, Hamaoka H, Kaneko M, Shigeta M, Abe T, Sekiguchi K, and Kondo Y
4) Gap junction-mediated contraction of myoepithelial cells induces the peristaltic transport of sweat in human eccrine glands
Nakashima K, Kato H, Kurata R, Luo Q, Hayakawa T, Okada F, Fujita F, Nakagawa Y, Tanemura A, Murota H, Katayama I, and Sekiguchi K
3) Laminin fragments conjugated with perlecan’s growth factor-binding domain differentiate human induced pluripotent stem cells into skin-derived precursor cells
Sugiyama‐Nakagiri Y, Yamashita S, Taniguchi Y, Shimono C, and Sekiguchi K
2) Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells
Sato-Nishiuchi R, Doiguchi M, Morooka N, and Sekiguchi K
J. Cell Biol., 222:e202208047 (2023).
1) Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries
Hamada Y, Ogata S, Masuda T, Ito S, and Ohtsuki S
Fluids Barriers CNS, 20:50 (2023).